Item Type | Name |
Concept
|
Acetylation
|
Concept
|
Australia
|
Concept
|
Algorithms
|
Concept
|
Alleles
|
Concept
|
Amino Acid Sequence
|
Concept
|
Antibody Formation
|
Concept
|
Cell Communication
|
Concept
|
Cell Membrane Permeability
|
Concept
|
Chromosomes, Human, Pair 11
|
Concept
|
Chromosomes, Human, Pair 6
|
Concept
|
Antibody Specificity
|
Concept
|
Base Sequence
|
Concept
|
Cell Count
|
Concept
|
Cell Differentiation
|
Concept
|
Cell Movement
|
Concept
|
DNA Damage
|
Concept
|
China
|
Concept
|
Binding Sites
|
Concept
|
Biological Transport
|
Concept
|
Drug Tolerance
|
Concept
|
California
|
Concept
|
Capillary Permeability
|
Concept
|
Cell Division
|
Concept
|
Biological Evolution
|
Concept
|
Exocytosis
|
Concept
|
Fertility
|
Concept
|
Chromosomes, Human, Pair 21
|
Concept
|
Cell Adhesion
|
Concept
|
Cell Cycle
|
Concept
|
Chromosomes, Human, Pair 12
|
Concept
|
Chemotaxis
|
Concept
|
Chicago
|
Concept
|
Genetic Vectors
|
Concept
|
Genital Neoplasms, Female
|
Concept
|
Glucosephosphate Dehydrogenase
|
Concept
|
Glutathione Transferase
|
Concept
|
Hematopoiesis
|
Concept
|
Cross Reactions
|
Concept
|
Drug Synergism
|
Concept
|
DNA Repair
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
Concept
|
Gene Frequency
|
Concept
|
Growth Inhibitors
|
Concept
|
Immunologic Surveillance
|
Concept
|
Chromosomes, Human, Pair 9
|
Concept
|
Exons
|
Concept
|
Drug Interactions
|
Concept
|
Drug Resistance
|
Concept
|
Introns
|
Concept
|
Endocytosis
|
Concept
|
Enzyme Activation
|
Concept
|
Myasthenia Gravis
|
Concept
|
Glioma
|
Concept
|
Glycosylation
|
Concept
|
Genes
|
Concept
|
Glioblastoma
|
Concept
|
Fibroblast Growth Factors
|
Concept
|
Obesity
|
Concept
|
Oncogenes
|
Concept
|
Dose-Response Relationship, Drug
|
Concept
|
Immune Tolerance
|
Concept
|
Immunologic Capping
|
Concept
|
Insulin-Like Growth Factor I
|
Concept
|
Energy Metabolism
|
Concept
|
Gene Amplification
|
Concept
|
Multigene Family
|
Concept
|
Goats
|
Concept
|
Mammary Glands, Animal
|
Concept
|
Membrane Glycoproteins
|
Concept
|
Michigan
|
Concept
|
Models, Genetic
|
Concept
|
Pregnancy
|
Concept
|
Molecular Sequence Data
|
Concept
|
Molecular Weight
|
Concept
|
Glycolysis
|
Concept
|
Oxidative Phosphorylation
|
Concept
|
Recombination, Genetic
|
Concept
|
Mutation
|
Concept
|
Genes, Intracisternal A-Particle
|
Concept
|
Microcirculation
|
Concept
|
Phosphorylation
|
Concept
|
Protein Binding
|
Concept
|
Protein Conformation
|
Concept
|
Protein Processing, Post-Translational
|
Concept
|
Glutamates
|
Concept
|
Radiation Injuries
|
Concept
|
Guanine
|
Concept
|
Residence Characteristics
|
Concept
|
Prothrombin Time
|
Concept
|
Radiation Dosage
|
Concept
|
Radiation Tolerance
|
Concept
|
Genes, ras
|
Concept
|
Risk
|
Concept
|
RNA Processing, Post-Transcriptional
|
Concept
|
Sensitivity and Specificity
|
Concept
|
Texas
|
Concept
|
Homeostasis
|
Concept
|
Leukocyte Count
|
Concept
|
Endothelial Growth Factors
|
Concept
|
Time Factors
|
Concept
|
Transcription, Genetic
|
Concept
|
Protein Biosynthesis
|
Concept
|
Genes, abl
|
Concept
|
United States
|
Concept
|
Electric Impedance
|
Concept
|
Hepatocyte Growth Factor
|
Concept
|
Sequence Homology, Amino Acid
|
Concept
|
Practice Guidelines as Topic
|
Concept
|
Genetic Variation
|
Concept
|
Radiation Pneumonitis
|
Concept
|
Phosphotransferases (Alcohol Group Acceptor)
|
Concept
|
Germ-Line Mutation
|
Concept
|
Locomotion
|
Concept
|
Gene Rearrangement
|
Concept
|
Drug Resistance, Neoplasm
|
Concept
|
Guanine Nucleotide Exchange Factors
|
Concept
|
rac1 GTP-Binding Protein
|
Concept
|
Protein Structure, Quaternary
|
Concept
|
Transforming Growth Factor beta
|
Concept
|
Up-Regulation
|
Concept
|
Lipid Peroxidation
|
Concept
|
Genes, Tumor Suppressor
|
Concept
|
Membrane Fluidity
|
Concept
|
Milk Proteins
|
Concept
|
Chi-Square Distribution
|
Concept
|
Gene Expression
|
Concept
|
Hematopoietic Cell Growth Factors
|
Concept
|
RNA Interference
|
Concept
|
Alternative Splicing
|
Concept
|
Protein Structure, Tertiary
|
Concept
|
Receptors, Fibroblast Growth Factor
|
Concept
|
Fractals
|
Concept
|
Genes, Reporter
|
Concept
|
Point Mutation
|
Concept
|
Apoptosis
|
Concept
|
Gene Deletion
|
Concept
|
Receptors, Growth Factor
|
Concept
|
Cell Proliferation
|
Concept
|
Oxidative Stress
|
Concept
|
GTP-Binding Protein alpha Subunits, Gi-Go
|
Concept
|
Gene Regulatory Networks
|
Concept
|
Protein Transport
|
Concept
|
Mutation, Missense
|
Concept
|
src Homology Domains
|
Concept
|
Pentose Phosphate Pathway
|
Concept
|
Protein Structure, Secondary
|
Concept
|
Vascular Endothelial Growth Factor Receptor-2
|
Concept
|
Green Fluorescent Proteins
|
Concept
|
Vascular Endothelial Growth Factors
|
Concept
|
Area Under Curve
|
Concept
|
Amino Acid Substitution
|
Concept
|
Cell Growth Processes
|
Concept
|
rac GTP-Binding Proteins
|
Concept
|
Amino Acid Motifs
|
Concept
|
Active Transport, Cell Nucleus
|
Concept
|
Loss of Heterozygosity
|
Concept
|
Databases, Genetic
|
Concept
|
Gene Expression Profiling
|
Concept
|
Allelic Imbalance
|
Concept
|
Animals, Genetically Modified
|
Concept
|
Promoter Regions, Genetic
|
Concept
|
Pupa
|
Concept
|
Interleukin Receptor Common gamma Subunit
|
Concept
|
DNA Breaks, Double-Stranded
|
Concept
|
Structure-Activity Relationship
|
Concept
|
Taiwan
|
Concept
|
Tissue Distribution
|
Concept
|
Receptors, Vascular Endothelial Growth Factor
|
Concept
|
Proteolysis
|
Concept
|
Epithelial-Mesenchymal Transition
|
Concept
|
Substrate Specificity
|
Concept
|
Temperature
|
Concept
|
Protein Interaction Domains and Motifs
|
Concept
|
Down-Regulation
|
Concept
|
Autoimmunity
|
Concept
|
DNA Copy Number Variations
|
Concept
|
Cell Death
|
Concept
|
Transfection
|
Concept
|
Wound Healing
|
Concept
|
Genetic Therapy
|
Concept
|
Molecular Structure
|
Concept
|
Genome, Human
|
Concept
|
Gene Expression Regulation, Enzymologic
|
Concept
|
Odds Ratio
|
Concept
|
Granulocyte Colony-Stimulating Factor
|
Concept
|
Genes, src
|
Concept
|
Genes, fos
|
Concept
|
Cell Polarity
|
Concept
|
Cellular Senescence
|
Concept
|
DNA Methylation
|
Concept
|
GTP-Binding Proteins
|
Concept
|
Gene Silencing
|
Concept
|
Gene Knockdown Techniques
|
Concept
|
Drug Resistance, Multiple
|
Concept
|
Tropism
|
Concept
|
Gene Dosage
|
Concept
|
Genes, erbB-2
|
Concept
|
Genetic Heterogeneity
|
Concept
|
Genistein
|
Concept
|
Inhibitory Concentration 50
|
Concept
|
GTPase-Activating Proteins
|
Concept
|
MAP Kinase Signaling System
|
Concept
|
Lymphangiogenesis
|
Concept
|
Gene Fusion
|
Concept
|
Cell Cycle Checkpoints
|
Concept
|
Transcriptome
|
Concept
|
G1 Phase Cell Cycle Checkpoints
|
Concept
|
Immune Evasion
|
Concept
|
Tumor Microenvironment
|
Concept
|
Vascular Endothelial Growth Factor A
|
Concept
|
Homologous Recombination
|
Concept
|
Protein Interaction Maps
|
Concept
|
Radiotherapy, Image-Guided
|
Concept
|
Cell Size
|
Concept
|
Cell Shape
|
Concept
|
Comparative Genomic Hybridization
|
Concept
|
Neoplasm Grading
|
Concept
|
Artificial Intelligence
|
Concept
|
Canada
|
Concept
|
Cell Physiological Phenomena
|
Concept
|
Cell Survival
|
Concept
|
Chromatin
|
Concept
|
Chromosome Aberrations
|
Concept
|
Enhancer Elements, Genetic
|
Concept
|
Epidermal Growth Factor
|
Concept
|
Genetic Testing
|
Concept
|
Genotype
|
Concept
|
Glucose
|
Concept
|
Growth Substances
|
Concept
|
Hemostasis
|
Concept
|
Heterozygote
|
Concept
|
Immunity
|
Concept
|
Kinetics
|
Concept
|
Lymphocyte Activation
|
Concept
|
Phenotype
|
Concept
|
Phylogeny
|
Concept
|
Thymus Gland
|
Concept
|
Translocation, Genetic
|
Concept
|
Glucuronosyltransferase
|
Concept
|
Signal Transduction
|
Concept
|
Transcriptional Activation
|
Concept
|
Gene Expression Regulation, Neoplastic
|
Concept
|
Granulocyte-Macrophage Colony-Stimulating Factor
|
Concept
|
Telomere
|
Concept
|
Genes, erbB-1
|
Concept
|
Genetic Predisposition to Disease
|
Concept
|
Polymorphism, Single Nucleotide
|
Concept
|
Maximum Tolerated Dose
|
Concept
|
Genomics
|
Concept
|
Potassium Channels, Voltage-Gated
|
Concept
|
Vascular Endothelial Growth Factor Receptor-1
|
Concept
|
Epigenesis, Genetic
|
Concept
|
Ubiquitination
|
Concept
|
Molecular Dynamics Simulation
|
Concept
|
GPI-Linked Proteins
|
Academic Article
|
p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.
|
Academic Article
|
Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).
|
Academic Article
|
Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL.
|
Academic Article
|
BCR/ABL induces multiple abnormalities of cytoskeletal function.
|
Academic Article
|
The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells.
|
Academic Article
|
The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors.
|
Academic Article
|
The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.
|
Academic Article
|
The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins.
|
Academic Article
|
Hematopoietic growth factors signal through the formation of reactive oxygen species.
|
Academic Article
|
Role of focal adhesion proteins in signal transduction and oncogenesis.
|
Academic Article
|
Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.
|
Academic Article
|
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.
|
Academic Article
|
The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.
|
Academic Article
|
Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells.
|
Academic Article
|
Molecular abnormalities in lung cancer.
|
Academic Article
|
Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.
|
Academic Article
|
Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines.
|
Academic Article
|
Gemcitabine and vinorelbine in patients with advanced lung cancer: preclinical studies and report of a phase I trial.
|
Academic Article
|
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
|
Academic Article
|
The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo.
|
Academic Article
|
A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.
|
Academic Article
|
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.
|
Academic Article
|
Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.
|
Academic Article
|
Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins.
|
Academic Article
|
BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration.
|
Academic Article
|
Role of the cytoskeletal protein paxillin in oncogenesis.
|
Academic Article
|
Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition.
|
Academic Article
|
Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma.
|
Academic Article
|
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.
|
Academic Article
|
Gemcitabine-induced radiation recall.
|
Academic Article
|
Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer.
|
Academic Article
|
Molecular alterations in lung cancer. Impact on prognosis.
|
Academic Article
|
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.
|
Academic Article
|
c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention.
|
Academic Article
|
Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells.
|
Academic Article
|
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
|
Academic Article
|
Molecular biology of malignant mesothelioma: a review.
|
Academic Article
|
Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer.
|
Academic Article
|
Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomas.
|
Academic Article
|
c-Met: structure, functions and potential for therapeutic inhibition.
|
Academic Article
|
Lung carcinoma in African Americans.
|
Academic Article
|
c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy.
|
Academic Article
|
Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia.
|
Academic Article
|
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription.
|
Academic Article
|
Phase I trial of erlotinib-based multimodality therapy for inoperable stage III non-small cell lung cancer.
|
Academic Article
|
EGFR-targeted therapeutics: focus on SCCHN and NSCLC.
|
Academic Article
|
Integrin-dependent protein tyrosine phosphorylation is a key regulatory event in collagen-IV-mediated adhesion and proliferation of human lung tumor cell line, Calu-1.
|
Academic Article
|
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.
|
Academic Article
|
Lymphatic vessel density is not associated with lymph node metastasis in non-small cell lung carcinoma.
|
Academic Article
|
The role of ephrins and Eph receptors in cancer.
|
Academic Article
|
Expression and mutational analysis of MET in human solid cancers.
|
Academic Article
|
MET pathway as a therapeutic target.
|
Academic Article
|
EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation.
|
Academic Article
|
Gefitinib response of erlotinib-refractory lung cancer involving meninges--role of EGFR mutation.
|
Academic Article
|
Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma.
|
Academic Article
|
PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene.
|
Academic Article
|
Ethnic differences and functional analysis of MET mutations in lung cancer.
|
Academic Article
|
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.
|
Academic Article
|
c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
|
Academic Article
|
Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.
|
Academic Article
|
Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin.
|
Academic Article
|
Preclinical studies of the proteasome inhibitor bortezomib in malignant pleural mesothelioma.
|
Academic Article
|
Fyn is downstream of the HGF/MET signaling axis and affects cellular shape and tropism in PC3 cells.
|
Academic Article
|
Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion.
|
Academic Article
|
Pathologic response rates following definitive dose image-guided chemoradiotherapy and resection for locally advanced non-small cell lung cancer.
|
Academic Article
|
FYN is overexpressed in human prostate cancer.
|
Academic Article
|
Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion.
|
Academic Article
|
Inhibition of MET receptor tyrosine kinase and its ligand hepatocyte growth factor.
|
Academic Article
|
Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.
|
Academic Article
|
Overexpression of the µ-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis.
|
Academic Article
|
Differential expression of RON in small and non-small cell lung cancers.
|
Academic Article
|
PAX3 and SOX10 activate MET receptor expression in melanoma.
|
Academic Article
|
Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.
|
Academic Article
|
Melanoma proteoglycan modifies gene expression to stimulate tumor cell motility, growth, and epithelial-to-mesenchymal transition.
|
Academic Article
|
MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance.
|
Academic Article
|
Multicenter phase II trial of Motexafin gadolinium and pemetrexed for second-line treatment in patients with non-small cell lung cancer.
|
Academic Article
|
MET and phosphorylated MET as potential biomarkers in lung cancer.
|
Academic Article
|
The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization.
|
Academic Article
|
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
|
Academic Article
|
Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions.
|
Academic Article
|
Role of protein kinase C ß and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model organism.
|
Academic Article
|
Inhibition of MET receptor tyrosine kinase and its ligand hepatocyte growth factor.
|
Academic Article
|
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
|
Academic Article
|
Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer.
|
Academic Article
|
Changes in Tc-99m radionuclide bone scan images and peripheralization of marrow hematopoietic activity associated with the administration of granulocyte colony stimulating factor as an adjunct to dose-intensified chemotherapy for breast cancer. A case report.
|
Academic Article
|
Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.
|
Academic Article
|
c-Met is a potentially new therapeutic target for treatment of human melanoma.
|
Academic Article
|
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.
|
Academic Article
|
Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.
|
Academic Article
|
Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
|
Academic Article
|
NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases.
|
Academic Article
|
Generation of comprehensive thoracic oncology database--tool for translational research.
|
Academic Article
|
Personalized treatment of lung cancer.
|
Academic Article
|
Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer.
|
Academic Article
|
Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer.
|
Academic Article
|
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis.
|
Academic Article
|
Development of The American Association for Thoracic Surgery guidelines for low-dose computed tomography scans to screen for lung cancer in North America: recommendations of The American Association for Thoracic Surgery Task Force for Lung Cancer Screening and Surveillance.
|
Academic Article
|
The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups.
|
Academic Article
|
Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma.
|
Academic Article
|
Inhibition of epidermal growth factor receptor signaling in malignant pleural mesothelioma.
|
Academic Article
|
Molecular and cellular biology of small cell lung cancer.
|
Academic Article
|
Haptoglobin alpha-subunit and hepatocyte growth factor can potentially serve as serum tumor biomarkers in small cell lung cancer.
|
Academic Article
|
A phase I study of pemetrexed, carboplatin, and concurrent radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancer.
|
Academic Article
|
Key signaling pathways and targets in lung cancer therapy.
|
Academic Article
|
CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin.
|
Academic Article
|
C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes.
|
Academic Article
|
Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.
|
Academic Article
|
Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease.
|
Academic Article
|
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.
|
Academic Article
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Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification.
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Academic Article
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Role of MetMAb (OA-5D5) in c-MET active lung malignancies.
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Academic Article
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Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence.
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Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers.
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Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis.
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The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target.
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A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer.
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MET as a possible target for non-small-cell lung cancer.
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Academic Article
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Critical role of S1PR1 and integrin ß4 in HGF/c-Met-mediated increases in vascular integrity.
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Teaching Video NeuroImages: myokymia and nerve hyperexcitability as components of Morvan syndrome due to malignant thymoma.
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The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer.
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Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.
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Activating the expression of human K-rasG12D stimulates oncogenic transformation in transgenic goat fetal fibroblast cells.
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Academic Article
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Expression of the EPHB4 receptor tyrosine kinase in head and neck and renal malignancies--implications for solid tumors and potential for therapeutic inhibition.
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Analysis of 1,115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic.
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Academic Article
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Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer.
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Academic Article
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Crizotinib in ROS1-rearranged non-small-cell lung cancer.
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Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides.
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Academic Article
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Multiple Endocrine Disruption by the MET/ALK Inhibitor Crizotinib in Patients With Non-small Cell Lung Cancer.
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Academic Article
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Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer.
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Academic Article
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Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer.
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Academic Article
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Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
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Evaluation of a novel rash scale and a serum proteomic predictor in a randomized phase II trial of sequential or concurrent cetuximab and pemetrexed in previously treated non-small cell lung cancer.
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Geographic variation in radiologist capacity and widespread implementation of lung cancer CT screening.
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Fibroblast growth factor signaling and inhibition in non-small cell lung cancer and their role in squamous cell tumors.
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A personalized treatment for lung cancer: molecular pathways, targeted therapies, and genomic characterization.
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A new hope for precision medicine.
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AXL mediates resistance to cetuximab therapy.
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Molecularly targeted therapies in non-small-cell lung cancer annual update 2014.
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Nuclear epidermal growth factor receptor is a functional molecular target in triple-negative breast cancer.
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c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury.
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AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma.
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Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer.
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A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).
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Academic Article
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Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.
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Academic Article
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PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma.
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Academic Article
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ROS1 rearranged non-small cell lung cancer brain metastases respond to low dose radiotherapy.
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Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
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Role played by paxillin and paxillin tyrosine phosphorylation in hepatocyte growth factor/sphingosine-1-phosphate-mediated reactive oxygen species generation, lamellipodia formation, and endothelial barrier function.
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Academic Article
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Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma.
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Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
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Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.
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Tumor Heterogeneity and Therapeutic Resistance.
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Mutation testing for directing upfront targeted therapy and post-progression combination therapy strategies in lung adenocarcinoma.
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Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization.
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Academic Article
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Comprehensive genetic testing identifies targetable genomic alterations in most patients with non-small cell lung cancer, specifically adenocarcinoma, single institute investigation.
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Post-crizotinib management of effective ceritinib therapy in a patient with ALK-positive non-small cell lung cancer.
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Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.
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Academic Article
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Activity and safety of brigatinib in ALK-rearranged non-small-cell lung cancer and other malignancies: a single-arm, open-label, phase 1/2 trial.
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Genomic mutation-driven metastatic breast cancer therapy: a single center experience.
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Academic Article
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RETRACTED: The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor.
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TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer.
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Molecular profiling of metastatic colorectal tumors using next-generation sequencing: a single-institution experience.
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Academic Article
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Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma.
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Academic Article
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CALGB 30103: A randomized phase II study of carboplatin and etoposide (CE) with or without G3139 in patients with extensive stage small cell lung cancer (ES-SCLC).
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Refining epidermal growth factor receptor (EGFR) -inhibition-related rash (EIRR) phenotypes with a cetuximab (C) monotherapy stage of a phase II trial for non-small cell lung cancer (NSCLC).
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Academic Article
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Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
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Academic Article
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MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale.
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Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.
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Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma.
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Academic Article
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Value-Based Medicine and Integration of Tumor Biology.
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Academic Article
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Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
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Academic Article
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Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL.
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Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target.
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The Genetic/Non-genetic Duality of Drug 'Resistance' in Cancer.
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Correction: Genomic mutation-driven metastatic breast cancer therapy: a single center experience.
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Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming.
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2'-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells.
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EphB4: A promising target for upper aerodigestive malignancies.
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2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.
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Academic Article
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Metastasis of breast tumor cells to brain is suppressed by targeting RLIP alone and in combination with 2'-Hydroxyflavanone.
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Academic Article
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The brigatinib experience: a new generation of therapy for ALK-positive non-small-cell lung cancer.
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Untying the gordion knot of targeting MET in cancer.
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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
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A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer.
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Academic Article
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Value-based genomics.
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The DNA walk and its demonstration of deterministic chaos-relevance to genomic alterations in lung cancer.
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Academic Article
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RLIP inhibition suppresses breast-to-lung metastasis.
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Academic Article
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RLIP: An existential requirement for breast carcinogenesis.
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The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.
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Academic Article
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Correction: Nuclear Epidermal Growth Factor Receptor Is a Functional Molecular Target in Triple-negative Breast Cancer.
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Synergistic efficacy of RLIP inhibition and 2'-hydroxyflavanone against DMBA-induced mammary carcinogenesis in SENCAR mice.
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Academic Article
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The Mitochondrion as an Emerging Therapeutic Target in Cancer.
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Academic Article
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Radiologic Considerations and Standardization of Malignant Pleural Mesothelioma Imaging Within Clinical Trials: Consensus Statement from the NCI Thoracic Malignancy Steering Committee - International Association for the Study of Lung Cancer - Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting.
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Academic Article
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USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks.
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Academic Article
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Dose-escalation trial of the ALK, MET & ROS1 inhibitor, crizotinib, in patients with advanced cancer.
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Academic Article
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer.
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Academic Article
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RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis.
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Academic Article
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SOX9: The master regulator of cell fate in breast cancer.
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Academic Article
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Presence and structure-activity relationship of intrinsically disordered regions across mucins.
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Academic Article
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Precision medicine and actionable alterations in lung cancer: A single institution experience.
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Academic Article
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Therapeutic targeting of miRNA-216b in cancer.
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Academic Article
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Targeting RLIP with CRISPR/Cas9 controls tumor growth.
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Academic Article
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AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer.
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Academic Article
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
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Academic Article
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Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies.
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Academic Article
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A Non-genetic Mechanism Involving the Integrin ß4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer.
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Academic Article
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Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease.
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Academic Article
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Erratum: A Non-genetic Mechanism Involving the Integrin ß4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer.
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Academic Article
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Hyperprogression on immunotherapy with complete response to chemotherapy in a NSCLC patient with high PD-L1 and STK11: A case report.
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Academic Article
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Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
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Academic Article
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Activating p53 function by targeting RLIP.
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Academic Article
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Prevention of mammary carcinogenesis in MMTV-neu mice by targeting RLIP.
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Academic Article
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The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC).
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Academic Article
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Group Behavior and Emergence of Cancer Drug Resistance.
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Academic Article
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RLIP depletion induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.
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Academic Article
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Therapeutic Potential of Olaparib in Combination With Pembrolizumab in a Young Patient With a Maternally Inherited BRCA2 Germline Variant: A Research Report.
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Quantifying Cancer: More Than Just a Numbers Game.
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RNA-based therapies: A cog in the wheel of lung cancer defense.
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ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation.
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Academic Article
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Germline mutations and age at onset of lung adenocarcinoma.
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Academic Article
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The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ß-Like 1-ß-Catenin Protein Complex.
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Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer.
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MicroRNA-1: Diverse role of a small player in multiple cancers.
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Academic Article
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Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM).
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Academic Article
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Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer.
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Academic Article
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Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
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Twitter as a Tool to Spread Communication Regarding Genitourinary Cancers During the COVID-19 Pandemic.
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Academic Article
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Dynamic Phenotypic Switching and Group Behavior Help Non-Small Cell Lung Cancer Cells Evade Chemotherapy.
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Academic Article
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Leveraging deep learning algorithms for synthetic data generation to design and analyze biological networks.
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Academic Article
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Exploring the Next Frontier in Non-Small-Cell Lung Cancer With High MET and Mutated Epidermal Growth Factor Receptor.
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Academic Article
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MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis.
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Academic Article
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Addressing the genetic/nongenetic duality in cancer with systems biology.
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Academic Article
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RLIP: A necessary transporter protein for translating oxidative stress into pro-obesity and pro-carcinogenic signaling.
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Academic Article
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Overcoming Barriers to Tobacco Cessation and Lung Cancer Screening among Racial and Ethnic Minority Groups and Underserved Patients in Academic Centers and Community Network Sites: The City of Hope Experience.
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Concept
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Cell Self Renewal
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Concept
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Machine Learning
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Concept
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Origin of Life
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Concept
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Forkhead Box Protein M1
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Concept
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Gene Editing
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Concept
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Maternal Inheritance
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Concept
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Protein Domains
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Concept
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Fanconi Anemia Complementation Group N Protein
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Concept
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Inhibitor of Growth Protein 1
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Concept
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Mitochondrial Dynamics
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Concept
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CRISPR-Cas Systems
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Grant
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ABNORMALITIES OF MOTILITY OF CML CELLS
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Grant
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Role of Paxillin in Lung Cancer
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Grant
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MINIMAL RESIDUAL TUMOR IN SMALL CELL LUNG CANCER
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Grant
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Role of c-Met in SCLC and Potential for Novel Therapy
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Grant
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Novel Targeted Therapy in Pancreatic Cancer
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Grant
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Studies of a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
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Grant
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PAXILLIN--AN ONCOGENE ACTIVATED PROTEIN
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Academic Article
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Twelve-Month Follow-up of the Immune Response After COVID-19 Vaccination in Patients with Genitourinary Cancers: A Prospective Cohort Analysis.
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Academic Article
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The innate effects of plant secondary metabolites in preclusion of gynecologic cancers: Inflammatory response and therapeutic action.
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Academic Article
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Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.
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Academic Article
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A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer.
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Academic Article
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Artificial intelligence and allied subsets in early detection and preclusion of gynecological cancers.
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